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Tags: NMDAR magnesium voltage 
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Author Topic: NMDAR magnesium voltage threshold  (Read 269 times)
wick
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« on: February 22, 2012, 07:58:31 AM »

Hi-
I'm an undergraduate studying neuroscience. My question is:

NMDA receptors have that magnesium ion blocking calcium entry even in the event of bound glutamate/glycine. I know that the shifting of the magnesium is "voltage-dependent", but what's the threshold? Is the sodium entering the spine locally via AMPARs enough to push it off? Or does the far-off axon need to depolarize? Or is it even a threshold? That is, is the amount of displaced Mg just sort of function of voltage?

If anybody could shed some light on this, it would be great.
-wick
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